Studies involving avermectin and the 4‐aminobutyric acid (GABA) receptor ofAscaris suummuscle

摘要

AbstractThis study describes the pharmacology of the Ascaris suum muscle GABA receptor using a range of GABA agonists and antagonists. The GABA receptor at this site does not readily fit into GABA‐A or GABA‐B classification. The effect of the potent anthehmintic, avermectin, on these cells was investigated. It was found to inhibit GABA‐evoked increase in membrane conductance and membrane hyper polarisation on quiescent muscle cells with an apparent affinity constant in the mid‐micromolar range. When applied to spontaneously active muscle cells, avermectin (I üM) inhibited the spiking activity after a delay of abou