Mutagenic lipid peroxides from edible oils

摘要

AbstractWeak mutagenic activity was detected in several commercially available edible palm and corn oils using liquid incubation bioassays withSalmonella typhimuriumTA1537. Chromatographic fractionation of unrefined palm oil established that mutagenic activity was present in three fractions that also contained fatty acyl hydroperoxides. Similar weak mutagenic activity was also demonstrated for linoleic and linolenic acid hydroperoxides. In all cases, the mutagenicity was abolished by exogenous catalase, implying that the observed activity was moderated by hydrogen peroxide.