Highly enantioselective amination of? 3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

摘要

The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of h3-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P-and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.