Combination therapy for disseminated strongyloidiasis with associated vancomycin‐resistant, linezolid‐intermediate Enterococcus faecium meningitis: A case report

摘要

Abstract What is known and objective The rhabditid nematode Strongyloides stercoralis is the major causative agent of disseminated strongyloidiasis (DS). In rare cases, DS has caused enterococcal meningitis. If DS‐associated vancomycin‐resistant Enterococcus faecium (VRE) meningitis is suspected, combination antibiotic therapy should be considered. Case Summary We present a case of a 61‐year‐old male who developed DS associated with vancomycin‐resistant and linezolid‐intermediate E. faecium meningitis after receiving corticosteroids. The VRE meningitis was treated with high‐dose daptomycin 12?mg/kg, linezolid, tigecycline and quinupristin/dalfopristin. Despite negative cultures, the patient expired. What is new and conclusion In patients with DS‐associated VRE meningitis, early use of combination therapy may be warranted to improve patient outcomes.