SUMMARYCefuroxime sodium (Zinacef®) is a new semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration which is stable to most of the β‐lactamases.The stability of cefuroxime sodium in aqueous solutions, with or without phosphate buffer, and in 5% dextrose and 0.9% sodium chloride injections was studied using a stability‐indicating high‐pressure liquid chromatographic method developed in our laboratory. The optimum pH range of stability was determined to be ˜ 4.5–7.3. Both buffered and unbuffered solutions followed first‐order decomposition. In 5% dextrose and 0.9% sodium chloride injections, cefuroxime was stable for 1 day (more than 90% potent) at 25°C and for at least 30 days at 5°C. At — 10°C, there was negligible decomposition after 30 days. The pH values of the solutions stored at 5°C and — 10°C remained in the maximum stability range and the solutions were clear even after 30 days of storage. Thawing the frozen solutions in a microwave oven adversely a
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