HPLC Quantification of Azintamide and Papaverine Hydrochloride Simultaneously in Pharmaceutical Preparations

摘要

A simple HPLC-procedure for quantification of azintamide and papaverine. HCl simultaneouly in dosage formulations has been investigated. The complete resolution and quantitative determination of both drug substances has been undertaken on a Hibar 100RP-18 Lichrospher (5 μm) column by using a solvent mixture composed of acetonirile – water (56:44, v/v) isocratically at a rate of 1 ml·min−1with UV-detection at 240 nm. Recovery percentages of 100.39 ± 0.70 (n = 12) and 99.97 ± 1.11 (n = 12) were obtained for added azintamide and papaverine. HCl, in order.