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Deep Learning for the Classification of Genomic Signals

机译:用于基因组信号分类的深度学习

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摘要

Genomic signal processing (GSP) is based on the use of digital signal processing methods for the analysis of genomic data. Convolutional neural networks (CNN) are the state-of-the-art machine learning classifiers that have been widely applied to solve complex problems successfully. In this paper, we present a deep learning architecture and a method for the classification of three different functional genome types: coding regions (CDS), long noncoding regions (LNC), and pseudogenes (PSD) in genomic data, based on the use of GSP methods to convert the nucleotide sequence into a graphical representation of the information contained in it. The obtained accuracy scores of 83 and 84 when classifying between CDS vs. LNC and CDS vs. PSD, respectively, indicate the feasibility of employing this methodology for the classification of these types of sequences. The model was not able to differentiate from PSD and LNC. Our results indicate the feasibility of employing CNN with GSP for the classification of these types of DNA data.
机译:基因组信号处理(GSP)是基于使用数字信号处理方法来分析基因组数据。卷积神经网络 (CNN) 是最先进的机器学习分类器,已被广泛应用于成功解决复杂问题。在本文中,我们提出了一种深度学习架构和方法,用于对基因组数据中的编码区(CDS)、长非编码区(LNC)和假基因(PSD)进行分类,基于GSP方法将核苷酸序列转换为其中包含的信息的图形表示。在CDS与LNC和CDS与.PSD之间进行分类时,分别获得83%和84%的准确率得分,表明采用这种方法对这些类型的序列进行分类的可行性。该模型无法与PSD和LNC区分开来。我们的结果表明,使用CNN和GSP对这些类型的DNA数据进行分类是可行的。

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