The lack of CNS effects of nizatidine, with and without alcohol, on psychomotor ability and cognitive function

摘要

AbstractThe aim of the study was to measure the effects of nizatidine (150 mg, 300 mg, and 600 mg), with and without alcohol (0.5 g/kg body weight) on a battery of test of psychomotor functioning, short‐term memory and subjective rating of sedation. A placebo and positive internal control (lorazepam 1 mg) crossover design was used, with each subject acting as her own control. The study population consisted of 10 healthy female volunteers with an age range of 20–50 years. The results show that nitatidine, at the range of doses studied, has no demonstrable effect on any of the measures of CNS activity and psychomotor performance. This lack of CNS effect was demonstrated in a study where the verum showed a consistent impairment of CNS activity. Furthermore there was no potentiation of the effects of alcohol by any of the doses of nizatidine u