Regional mapping of the gene for autosomal dominant spinocerebellar ataxia (SCA1) by localizing the closely linked D6S89 locus to 6p24.2→p23.05

摘要

The locus for one subtype of autosomal dominant spinocerebellar ataxias (SCA1) is closely linked (within 1–2 cM) to D6S89, which contains a highly polymorphic dinucleotide repeat sequence. D6S89 has been mapped previously to 6p24→p21.3, between the HLA and F13A1 loci. Mutant cell lines were used to correlate the absence or presence of D6S89 with cytogenetically detectable interstitial 6p deletions. The results allowed us to map D6S89 to the 6p24.2→p23.05 region. The close linkage of SCA1 to D6S89 indicates that this locus is most likely located in the 6p24→p23