In this study, we investigated the feasibility and physiologic effects of exercise during hemodialysis treatment when compared with submaximal work during non‐hemodialysis treatment times. In four subjects, an identical work load was administered, both during and off the hemodialysis treatment. There was no significant difference in heart rates, systolic blood pressures, diastolic blood pressures, perceived exertions, oxygen uptake, pulmonary ventilations, and carbon dioxide ventilations between the two exercise times. With exercise in both groups, the pulmonary ventilation, oxygen uptake, and carbon dioxide ventilation rose significantly. Submaximal exercise done during hemodialysis treatment is well tolerated, and the physiologic responses are similar. The abnormally high potassium response to exercise off dialysis, but not with dialysis, suggests that hemodialysis treatment may be a safer environment in which to carry out submaximal exercise in the chronic hemodialysis patient.
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