Men with liver disease are hypogonadal and feminished. European workers consider the liver disease itself to be the major factor but American workers blame alcohal consumption. We studied sexual dysfunction and sex hormones in three matched groups of men; controls (n=22), those with alcoholic liver disease (n=21), and those with non-alcoholic liver disease (n=21). Men with alcoholic liver disease had maore sexual dysfunction. Testosterone and androsastenedione concentrations were lower and oestradiaol and dehydroepiandrosterone sulphate levels were raised in the liver disease groups. The changes were greatest in the alcoholic liver disease group. In this, the first controlled study, liver diseaseper seappeares to cause sexual dysfunction and sex hormone changes but these changes are amplified by ethanol.
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