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外文期刊>european journal of immunology
>Specific helper T cell reactivity against autologous erythrocytes implies that self tolerance need not depend on clonal deletion
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Specific helper T cell reactivity against autologous erythrocytes implies that self tolerance need not depend on clonal deletion
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机译:Specific helper T cell reactivity against autologous erythrocytes implies that self tolerance need not depend on clonal deletion
AbstractUsing a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)‐reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activated by stimulation with RBC. Upon restimulationin vitrothese cells proliferate specifically against mouse RBC with the kinetics and magnitude characteristic of a secondary response. Since autologous RBC are toleratedin vivoin spite of the presence of such specifically reactive T helper cells, these findings imply that self tolerance, even to certain nonse‐questered antigens, may depend largely on regulatory mechanisms rather than on clonal deletion or inactivat
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