In The Lancet Neurology, Matthew Traylor and colleagues report the results of the largest pooled analysis of risk genes for lacunar stroke published to date. The authors included morethan 7000 patients with lacunar stroke and 250000 controls. In almost 3000 cases, MRI confirmed the presence of lacunar stroke. Patients were recruited from the UK DNA Lacunar Stroke studies 1 and 2 and by the collaborators of the International Stroke Genetics Consortium. The authors did a genome-wide association study (GWAS) for lacunar stroke alone, as well as a multi-trait approach with a phenotype including both lacunar strokes and white matter hyperintensities. They also did a transcriptome-wide association study, which identified transcribed genes related to lacunar stroke.
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