The free cytoplasmic Ca2+levels in duchenne muscular dystrophy lymphocytes

摘要

AbstractAn increased cellular Ca2+content has been associated with Duchenne muscular dystrophy (DMD). However, estimates of the free cytoplasmic Ca2+concentration ([Ca2+]i) in cells of DMD patients were not available. We compared the [Ca2+]i levels of normal and DMD peripheral blood lymphocytes and Epstein‐Barr virus‐transformed lymphoblasts using the novel probe, quin 2, an internally trapped fluorescent indicator. The [Ca2+]i levels of normal and DMD cells were not significantly differ