The T cell receptor β genes ofXenopus

摘要

AbstractcDNA of the T cell receptor β (TCRB) have been isolated from the anuran amphibianXenopusand they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of theXenopusTCRB constant region is the lack of N‐linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of theXenopus laevisandX. gilliused in this stu