The retention behaviour of some organic acids (N-phenylamides of benzoylacetic acid, phenolic acids and analgesic drugs) as model substances was investigated in reversed phase systems consisting of octadecyl silica (ODS) as a column packing material eluted with the buffer-methanol mixtures containing low concentrations of cetyltrimethylammonium bromide (cetrimide), tetrabutylammonium chloride (TBA-C1), tetraethylammonium chloride (TEA-C1) and di(2-ethylhexyl) orthophosphoric acid (HDEHP). The chain length of the n-alkyl group of the ion-pair reagent and the content of a modifir in the eluent contribute to rtention. Correlation between log k and log P and biological activity of N-phenylamides was analysed.
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