The presentation of recurrent odontogenic keratocysts of the mandible with an emphasis on the tooth-bearing area: a systematic review and meta-analysis

摘要

Aim: To gain insight in the actual ratio of recurrent odontogenic keratocysts (OKCs) occurring in the tooth-bearing area as compared to the posterior region of the mandible in order to come up with reliable data to base upon a rational treatment policy. Material and Methods: We searched MEDLINE, Web of Science, Scopus, Cochrane Library and Google Scholar databases for studies reporting on the location of recurrent mandibular OKCs. Risk Difference with a confidence interval of 95% of having the lesion in the tooth-bearing area versus the posterior region was the effect measure. P value for the summary effect of <0.05 was considered statistically significant. Results: The 1411 records retrieved were reduced to 13 studies to be qualitative/quantitative assessed. The pooled values showed that the difference in the clinical risk of having recurrent OKCs in the posterior region of the mandible and in the tooth-bearing area of the maxilla is of 7% (CI: -0.08, 0.22; P = 0.36), the posterior region being more susceptible to develop a recurrent OKC. Conclusions: The recurrence rate of OKCs in the posterior mandible is not significantly higher than of those located in the tooth-bearing part of the mandible; however, there is no reason to follow a more aggressive treatment policy for OKCs in the tooth-bearing area.