We read with special interest the elegant article by Sa-watzky and colleagues1 regarding the involvement of apoptosis-modulating proteins in the resolution of acute inflammation in vivo. One of the findings described by the authors was that in contrast to specific inhibitors of ERK-1/2 proteins, the flavonoid apigenin, which is a nonspecific inhibitor of ERK and Cox-2, actually exacerbated inflammation. Apigenin is a phytopolyphenol widely distributed in the human diet. Like many other flavonoids, apigenin has been reported to exert anti-inflammatory effects such as lowering oxidative stress and preventing the expression of several inflammatory factors, as confirmed by Sawatzky and collaborators
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