AbstractTheNKG2family of genes encodes at least four different type II transmembrane molecules (NKG2‐A, NKG2‐B, NKG2‐C and NKG2‐E) which contain a C‐lectin domain. These proteins have been shown to be covalently associated with CD94, another C‐type lectin member. The heterodimers are involved in natural killer cell‐mediated recognition of different HLA‐allotypes. Here we describe the cloning of a newNKG2‐related gene, termedNKG2‐F, localized 25 kb fromNKG2‐Aas well as its relationship with the previously describedNKG2‐DcDNA. Despite the similarities with the otherNKG2genes,NKG2‐Fencodes a putative protein which does not contain any lectin domain. However, a conserved 24‐amino acid sequence, present in all members of the NKG2 family, suggests that NKG2‐F is also able t
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