Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.
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机译:抗原特异性淋巴细胞参与发炎关节内的滑膜增殖。类风湿性关节炎患者的活化淋巴细胞和滑膜细胞表达可结合 TNF 相关细胞凋亡诱导配体 (TRAIL) 的受体。一项新的研究表明,在胶原诱导的关节炎和关节炎症模型中,用胶原蛋白脉冲并用能够表达 TRAIL 的基于腺病毒的载体转导的 DC 限制了关节炎的发生率。这些结果表明,基因修饰细胞疗法是系统性风湿性疾病的一种治疗选择。
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