Chromosome sublocalization of a cDNA for human DNA polymerase-β to 8p11→p12

摘要

We have localized a cDNA fragment that codes for human DNA polymerase-β. Using somatic cell and in situ hybridization techniques, this cDNA was cloned by screening a human KM-3 cell cDNA library in λgt 11 for expression of fused β-galactosidase-human DNA polymerase-β proteins. We have mapped this human polymerase-β gene to the short arm of chromosome 8 in the subregion 8p11