An approach for monitoring the redox activation of drug delivery in cobalt(III) complexes by in situ NMR spectroscopy is proposed. The reduction of the heteroleptic cobalt(III) complexes containing the 6,7-dihydroxycoumarin molecule applied as a model drug is studied using the proposed approach. The replacement of the bipyridine ligand in the cobalt(III) complex by phenanthroline considerably increases the redox-activated release rate of the drug.
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