Increased maternal serum aquaporin‐9 expression in pregnancies complicated with early‐onset preeclampsia

摘要

Abstract Objectives We aimed to evaluate maternal serum aquaporin‐9 (AQP9) concentrations in patients with early‐onset preeclampsia and compare them with the uncomplicated control group with normal blood pressure. Methods This was a prospective case–control study including pregnant women who were diagnosed with early‐onset preeclampsia between 200/7–340/7 weeks of gestation. Demographic and clinical characteristics, complete blood count and biochemical parameters, and serum AQP9 concentrations were documented. A receiver operating characteristic (ROC) curve was constructed to illustrate the sensitivity and specificity performance characteristics of AQP9 and a cut‐off value was estimated by using the Youden index. Results The mean serum concentrations of maternal AQP9 were significantly increased in the early‐onset preeclampsia group (722.22?±?211.80?pg/mL) than the control group (499.97?±?68.89?pg/mL, p?