Radiation therapy is administered both in curative and palliative settings, and it displays one of the most important modalities in interdisciplinary treatment regimes. Innovative concepts and developments were presented at ASCO 2010: the acceleration of postoperative radiotherapy can compensate for inferior survival rates in patients with oral cavity tumors not eligible for chemotherapy with cisplatin. Hyperfractionated accelerated radiotherapy achieves high survival rates in patients with limited stage small cell lung cancer at manageable toxicity rates. Patients with intermediate risk prostate cancer are treated safe-ly and effectively with hypofractionated radiation treatment regimes. Stereo-tactic salvage radiosurgery can be offered to patients following neurosurgical ivsection of 1-4 brain metastases instead of whole brain radiotherapy, wheiv ii achieves equivalent survival rates with lower toxicity. Patients with gastric cancer do not profit from postoperative chemoradiation following preoperai i-ve chemotherapy and surgery; the role of postoperative chemoradiatiwn following incomplete resection, in patients with nodal involvement or in non-ivsponders to preoperative chemotherapy remains unclear. Patients aged >=65 years with glioblastomas profit from chemoradiation with concomitant and adjuvant temozolomide chemotherapy independently of their MGMT methylation status.
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