Effects of postural change from supine to head-up tilt on the skin sympathetic nerve activity component synchronised with the cardiac cycle in warmed men

摘要

In humans, the cutaneous vasodilatation response to hyperthermia has been suggested to be suppressed by baroreflexes to maintain arterial pressure when the posture is changed from supine to upright, and if the reflexes do not function sufficiently, it can cause heat syncope. However, the efferent signals of the reflexes have not been identified. To identify the signals, we continuously measured skin sympathetic nerve activity (SSNA; microneurography), right atrial volume (RAV; echocardiography, the baroreceptors for the reflexes are reportedly located in the right atrium), cutaneous vascular conductance on the chest (CVCchest; laser Doppler flowmetry), and oesophageal temperature (T-oes; thermocouple) in young men before and after passive warming with a perfusion suit, during which periods the posture was changed from supine to 30deg head-up tilt positions. During these periods, we also simultaneously measured muscle sympathetic nerve activity (MSNA) to distinguish the SSNA from MSNA. We found that an increase in T-oes by approximate to 0.7 degrees C (P0.26) although an increase in CVCchest (P<0.019) was suppressed and RAV was reduced (P<0.008). In contrast, the SSNA component synchronised with the cardiac cycle increased in hyperthermia (P<0.015), but decreased with the postural change (P<0.017). The SSNA component during the postural change before and after warming was highly correlated with the CVCchest (r=0.817, P<0.0001), but the MSNA component was not (r=0.359, P=0.085). Thus, the SSNA component synchronised with the cardiac cycle appeared to be involved in suppressing cutaneous vasodilatation during postural changes.