PRIMARY INTRACRANIAL PLASMA CELL GRANULOMA RESPONSIVE TO RITUXIMAB

摘要

Plasma cell granuloma (PCG) is a sporadically occurring tumor-like mass that is histologically characterized by a non-neoplastic proliferation of inflammatory cells. The predominant cell types in PCG are polyclonal plasma cells and their precursors, including a substantial amount of mature B cells.PCGs can manifest in different organs and occur most commonly in the lung. Primary intracranial PCG is rare and its treatment poses an interdisciplinary challenge. Surgical resection is considered to be first-line treatment in PCG. Patients with non-resectable PCG are usually treated by radiotherapy or maintenance therapy with corticosteroids. However, those treatments have significant side effects and often fall short in reducing the tumor mass. In addition, recurrence is frequently observed, especially in cases of subtotal excision, which emphasizes the need for more specific long-term therapies with fewer adverse effects.