Differences of quantities of superoxide released from rat organs between in pathophysiological conditions and in normal conditions

摘要

Superoxide, one of reactive oxygen species, has been well known as risk factor for onset and progression of pathological conditions. Generally, superoxide is kept its balance between generation and dismutation. However, in pathophysiological conditions, superoxide may be generated excessively and give damage to tissue. It is assumed that there are differences in quantity of superoxide production between organs and pathological stages. We measured quantity of superoxide production in several organs isolated from Dahl salt sensitive rat (hypertension) and normal rat by chemiluminescence method. Quantities of superoxide production from hypertension rat were larger than that of normal rat in heart, kidney and liver. We conclude that superoxide may be play in onset and maintenance of hypertension.