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Effects of Aminoglutethimide on Ovarian Histology in the Rat

机译:氨基谷氨酰亚胺对大鼠卵巢组织学的影响

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Aminoglutethimide, a corticosteroid inhibitor, administered at a daily dose of 150 mg per kg body weight, showed a dramatic interference with ovarian histology in the rat. The drug caused thinning of the germinal epithelium and disruption of the layers of the follicular cells. It also resulted in the appearance of cytoplasmic vacuoles and distortion of follicle cell nuclei. In the corpus luteum, it caused shrinkage of the lutein cells, resulting in large spaces between the cords of cells. It also arrested immature follicles at various stages of their development. Our results indicate that aminoglutethimide, by modifying ovarian structure in the rat, interferes with the ovulation process.
机译:氨基谷氨酰亚胺是一种皮质类固醇抑制剂,日剂量为每公斤体重150毫克,对大鼠的卵巢组织学有显着干扰。该药物导致生发上皮变薄和滤泡细胞层的破坏。它还导致细胞质液泡的出现和卵泡细胞核的扭曲。在黄体中,它导致叶黄素细胞萎缩,导致细胞索之间的空间很大。它还在发育的各个阶段阻止了未成熟的卵泡。我们的结果表明,氨基谷氨酰亚胺通过改变大鼠的卵巢结构,干扰排卵过程。

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