Dear Sir, In a recent editorial [1], we described an online resource (Covid-age) that has been developed to assist health professionals in the assessment of patients' personal vulnerability to Covid-19, when advising on job placement. The article included a table showing risk estimates in the model as it stood at 16 July 2020. For most co-morbidities, those relative risks were derived from summary estimates across adults of all ages. New evidence has now emerged that the relative risks associated with some co-morbidities vary importantly with age, values being higher than average in younger adults. For example, the estimated relative risk for severe asthma rises from 1.2 (equivalent to 2 added years of age) at Age 75 up to 4.7 (equivalent to 15 added years of age) at Age 20. The age interaction is particularly marked for chronic kidney disease, with relative risks at Age 20 some 50-fold higher than at Age 75. In contrast, for mild asthma (i.e. not treated with oral corticosteroids in the past year), no age interaction is apparent.
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