Optical Coherence Tomography: An Alternative Methodology to Monitor Pharmaceutical Coating Processes

摘要

Optical coherence tomography (OCT) features a contact-free non-destructive technique, offering high resolution images of internal structures of materials. It represents an alternative process monitoring technology for coating processes, which does not depend on calibration models as are required for spectroscopic methods. Due to its high acquisition rate-OCT enables the measurement of local parameters of film-coated pellets or tablets even for fast moving samples and therefore, features a perfect in-line process monitoring technology.