Myocardial Ischemia Induces SDF-1 alpha Release in Cardiac Surgery Patients

摘要

In the present observational study, we measured serum levels of the chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) in 100 patients undergoing cardiac surgery with cardiopulmonary bypass at seven distinct time points including preoperative values, myocardial ischemia, reperfusion, and the postoperative course. Myocardial ischemia triggered a marked increase of SDF-1 alpha serum levels whereas cardiac reperfusion had no significant influence. Perioperative SDF-1 alpha serum levels were influenced by patients' characteristics (e.g., age, gender, aspirin intake). In an explorative analysis, we observed an inverse association between SDF-1 alpha serum levels and the incidence of organ dysfunction. In conclusion, time of myocardial ischemia was identified as the key stimulus for a significant upregulation of SDF-1 alpha, indicating its role as a marker of myocardial injury. The inverse association between SDF-1 alpha levels and organ dysfunction association encourages further studies to evaluate its organoprotective properties in cardiac surgery patients.