Metal- And Light-Free Direct C-3 Ketoalkylation of Quinoxalin-2(1H)-Ones with Cyclopropanols in Aqueous Medium

摘要

Direct oxidative C-3 ketoalkylation of quinoxalin-2(1H)-ones with cyclopropanols using ammonium persulfate in an aqueous medium has been achieved in a moderate to good yield. The reaction does not require metals, light-source, or catalysts to facilitate the reaction and could be efficiently utilized to construct a wide range of biologically relevant 3-ketoalkylated quinoxalin-2( 1H)-ones.