Direct and Regioselective C-H Selenylation of 4-Aminocoumarin Derivatives Mediated by Selectfluor~R

摘要

A mild and regioselective approach to the direct selenylation of 4-(N-substituted-amino)-2H-chromen-2-ones employing Selectfluor ~R and diorganyl diselenides has been developed.The reactions were carried out under metal-free conditions,without the need for special devices,and using NaHCO3 as a mild base at room temperature under air.This approach has been suitable for a wide substrate scope affording the 3-selenyl-4-(Nsubstituted-amino)-2H-chromen-2-ones in good to excellent yields.