3-Nitro-2H-chromene and derivatives are the significant structural building blocks of many natural products and pharmacologically active compounds. So, great deals of effort have been made for the development and improvement of 3-nitro-2H-chromene functionalized scaffolds by utilizing different methodologies. Among the various strategies, Michael/hetero-Michael addition reactions to 3-nitro-2H-chromene have been established as the most vibrant and unique research area for the construction of diverse CC and CX (X = heteroatoms) bonds providing versatile 2H-chromene frameworks. In recent years, a broad range of efficient Michael donors has been explored extensively which motivates the scientific community to work on these useful 2H-chromene frameworks in presence of different bases, transition metals, organocatalysts, and base/ catalyst-free conditions. Considering the importance of this research field, the present review highlights the major advancements of Michael/hetero-Michael addition reaction to 3-nitro-2H-chromenes utilizing various Michael donors from the year 2010 to 2022 in a comprehensive manner.
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