Post-Extrasystolic Potentiation as?a?Predictor of Recovery of Left?Ventricular?Dysfunction After Radiofrequency Catheter Ablation

摘要

Abstract Objectives This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation. Background Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat. Methods We performed a retrospective study of patients with a PVC burden of?≥10% PVC/24 h and left ventricular ejection fraction (LVEF) of? Results Sixty-one patients (age 68 ± 11 years, 98% male) were studied: 30 with preserved and 31 with reduced LVEF. During median follow-up of 9.4 months, the LVEF of 17 of 31 reduced EF patients improved (reversible) but 14 did not (irreversible). The post-PVC beat systolic blood pressure (SBP) (mm?Hg) increase ranged from 12.1 in control subjects (LVEF >50%) to 11.5 in reversible patients to 5 in irreversible patients. In multivariate analysis, the independent predictors of reversible LV function were post-PVC SBP rise (odds ratio [OR]: 4.61; 95% confidence interval [CI]: 1.45 to 15.83 per 5-mm Hg increase; p? Conclusions In patients with LV dysfunction and frequent PVC, post-PVC SBP accentuation may be a marker for?subsequent recovery of LVEF after ablation in presumed PVC-induced cardiomyopathy. Graphical abstract Display Omitted