Ascending Defibrillation Waveform Significantly Reduces Myocardial Morphological Damage and Injury Current

摘要

OBJECTIVES This study tested the hypothesis that a biphasic defibrillation waveform with an ascending first phase (ASC) causes less myocardial damage by pathology and injury current than a standard biphasic truncated exponential (BTE) waveform in a swine model.BACKGROUND Although lifesaving, defibrillation shocks have significant iatrogenic effects that reduce their benefit for patient survival.METHODS An ASC waveform with an 8-ms linear ramp followed by an additional positive 0.5-ms decaying portion with amplitudes of 20 J (ASC 20J) and 25 J (ASC 25J) was used. The control was a 25-J BTE conventional waveform (BTE 25J)