TOMM40 ' 523 variant and cognitive decline in older persons with APOE epsilon 3/3 genotype

Yu Lei; Lutz Michael W.; Wilson Robert S.Burns Daniel K.Roses Allen D.Saunders Ann M.Gaiteri ChrisDe Jager Philip L.Barnes Lisa L.Bennett David A.

首页> 外文期刊>Neurology: Official Journal of the American Academy of Neurology >TOMM40 ' 523 variant and cognitive decline in older persons with APOE epsilon 3/3 genotype

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TOMM40 ' 523 variant and cognitive decline in older persons with APOE epsilon 3/3 genotype

机译：TOMM40 523变种和认知下降老年人与APOEε3/3基因型

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Objective: To interrogate a poly-T variant (rs10524523,'523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE epsilon 3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD).

机译：摘要目的:询问poly-T变体在TOMM40 (rs10524523, 523),基因相邻APOE基因19号染色体上的老年人与APOEε3/3纯合性与认知能力下降,临床阿尔茨海默病(AD)的标志。

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来源
《Neurology: Official Journal of the American Academy of Neurology》 |2017年第7期|661-668|共8页
作者
Yu Lei; Lutz Michael W.; Wilson Robert S.Burns Daniel K.Roses Allen D.Saunders Ann M.Gaiteri ChrisDe Jager Philip L.Barnes Lisa L.Bennett David A.;
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作者单位

Duke Univ, Sch Med, Dept Neurol, Durham, NC 27706 USA;

Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA;

Zinfandel Pharmaceut Inc, Res Triangle Pk, NC USABrigham & Womens Hosp, Program Translat NeuroPsychiat Genom, Inst Neurosci, Dept Neurol, 75 Francis;

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原文格式 PDF
正文语种英语
中图分类神经病学;
关键词
Chromosomes, Human, Pair 19; Alzheimer Disease; aged personCognitive DeclineTOMM40 geneApolipoprotein E Gene;

机译：染色体,人类,一对19;阿尔茨海默病personCognitive DeclineTOMM40 geneApolipoproteinE基因;

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1. TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE epsilon 3 Homozygotes [J] . Watts Amber, Wilkins Heather M., Michaelis Elias, Journal of Alzheimer's disease: JAD . 2019,第4期

机译：Tomm40'523 Apoe epsilon 3 homozygotes的基线和纵向认知的关联
2. Association Between the APOE epsilon 2/epsilon 4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans [J] . Ren Dianxu, Lopez Oscar L., Lingler Jennifer H.Conley Yvette Journal of Alzheimer's disease: JAD . 2021,第3期

机译：Association Between the APOE epsilon 2/epsilon 4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans
3. Peripheral Transport Proteins Were Associated with 4-Year Cognitive Decline in APOE epsilon 4 Non-Carriers: A Longitudinal, Population-Based Study [J] . Gao Ling, Dang Liangjun, Wei ShanHu NingweiGao FanPeng WeiShang SuhangZhao YiChen ChenGuo XiaojuanHuo KangWang JingyiWang JinQu Qiumin Journal of Alzheimer's disease: JAD . 2022,第2期

机译：Peripheral Transport Proteins Were Associated with 4-Year Cognitive Decline in APOE epsilon 4 Non-Carriers: A Longitudinal, Population-Based Study
4. Metabolic syndrome, APOE epsilon4 and brain microstructure in HIV-infected individuals. [D] . Nakamoto, Beau K. 2010

机译：艾滋病毒感染者的代谢综合征，APOE epsilon4和脑微结构。
5. TOMM40 ‘523 GENE ASSOCIATED WITH COGNITIVE PERFORMANCE AND DECLINE AMONG NON-APOE E4 CARRIERS [O] . A Watts, E Michaelis, R Swerdlow -1

机译：TOMM40′523基因与非APOE E4载体的认知性能和下降相关
6. TOMM40 ‘523 GENE ASSOCIATED WITH COGNITIVE PERFORMANCE AND DECLINE AMONG NON-APOE E4 CARRIERS [O] . A Watts, E Michaelis, R Swerdlow 2018

机译：Tomm40'523基因与认知性能相关，非Apoe E4载体的下降

TOMM40 ' 523 variant and cognitive decline in older persons with APOE epsilon 3/3 genotype

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