APOE e4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

摘要

This study tested the hypothesis that the association between greater white matter hyperintensity (WMH) burden and worsened cognition in patients with Alzheimer disease (AD) and dementia with Lewy bodies (DLB) is stronger in persons who carry the APOE e4 allele than in noncarriers, and it found that the association may only be present in allele-carriers.