Lp-PLA2 and dual antiplatelet agents in intracranial arterial stenosis

摘要

To evaluate the interaction effect of lipoprotein-associated phospholipase A2 (Lp-PLA2) ac-tivity on the efficacy and safety of dual/single antiplatelet therapy in patients with and without intracranial arterial stenosis (ICAS) by the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events trial.Patients with both MRI analysis and Lp-PLA2 testing results were included in the current subanalysis. The interaction of Lp-PLA2 activity with the effects of dual and single antiplatelet therapy were analyzed through Cox proportional hazards regressions model.