Two cases of lumbosacral myeloradiculitis with anti-aquaporin-4 antibody.

摘要

Neuromyelitis optica (NMO) is an inflammatory disease of the CNS which is typically characterized by severe optic neuritis and transverse myelitis. Since the discovery of anti-aquaporin-4 (AQP4) antibody, an NMO-specific autoantibody, other unique features of NMO have been clarified. NMO lesions tend to be localized in site of AQP4 expression, such as dorsomedial medulla lesions or hypo-thalamic lesions. Here we report 2 cases of NMO spectrum disorders (NMOSD) with lumbosacral myeloradiculitis.