DECREASED IRON LEVELS IN THE TEMPORAL CORTEX IN POSTMORTEM HUMAN BRAINS WITH PARKINSON DISEASE

摘要

Objective: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with theiron-responsive element (IRE), transferrin receptor 1 (TfRl), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in thetemporal cortex of human brains with Parkinson disease (PD).Methods: Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfRl, and FPN1 expressionswere determined by Western blotting.Results: Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matchedhealthy controls. Unexpectedly, the levels of DMT1+IRE, TfRl, FPN1, and IRP1 were decreased in the temporal cortex inPD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.Conclusions: Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism mayexist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.