Transforming trial results into practice change: the final translational hurdle: Comment on 'Impact of the ALLHAT/JNC7 Dissemination Project on thiazide-type diuretic use'.

摘要

The connection between clinical research and typical patient care presents a frustrating paradox. Many well-documented advances in therapy are not adopted widely or quickly, whereas other, unimpressive new treatments are taken up in epidemic proportions, their use often fueled by marketing campaigns that are far more powerful than the medicines being advertised.1 As a result, patients are frequently exposed to new therapies that may be less effective or less safe than the older regimens they replace. For example, ezetimibe (Zetia and Vytorin; Merck/Shering-Plough Pharmaceuticals, North Wales, Pennsylvania) may not prevent atherosclerosis as well as the statin-only regimens it displaces for many patients