A three-year-old female neutered Staffordshire Bull Terrier underwent partial pancreatectomy for suspected insulinoma. During surgery, the patient developed severe hypotension unresponsive to reduction in inhalant agent concentration, intravenous fluid bolus therapy and intravenous administration of vasopressor agents. A progressive increase in arterial blood pressure values was only detected concomitantly with intravenous administration of methylene blue (MB), requested by the surgeon to facilitate the visualization of the pancreatic tumour. The arterial blood pressure remained within normal range values during the rest of the intraoperative period. The dog recovered uneventfully from general anaesthesia. To the author's knowledge, this is the first case report describing the effect of intravenous MB on arterial blood pressure in veterinary medicine.
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