The use of telmisartan in combination therapy in the management of nephrotic syndrome due to non-immune-mediated glomerulonephropathy in a young cat

摘要

An 8-month-old male castrated domestic shorthair was referred with anorexia, polydipsia, lethargy and diarrhoea, which progressed to marked subcutaneous oedema. The cat had hypoalbuminaemia, hypercholesterolaemia, proteinuria and oedema; clinicopathological findings consistent with severe protein-losing nephropathy and nephrotic syndrome. Histopathology of ultrasound-guided percutaneous renal biopsies identified marked podocyte injury with associated focal segmental glomerulosclerosis, a condition rarely reported in cats. The cat fully recovered following medical management with prednisolone and telmisartan, with the resolution of proteinuria.