Prophylaxis for recurrent urinary tract infections: nitrofurantoin, not trimethoprim-sulfamethoxazole or cranberry juice.

摘要

I read with interest the article by Beerepoot et al on urinary tract infection (UTI) prophylaxis, which raises important points that merit comment. From a resistance perspective, the article re-emphasizes that tri-methoprim-sulfarnethoxazole (TMP-SMX) is a "high resistance potential" antibiotic that predisposes to resistance among uropathogens. Clinicians should be reminded that resistance is not related to antibiotic volume, duration, or class per se, but rather is associated with individual agents from all antibiotic classes. Nitro-furantoin does not predispose to uropathogen resistance for prophylaxis and therapy of short or long duration.