首页> 外文期刊>Neurology: Official Journal of the American Academy of Neurology >Primary systemic amyloidosis with ischemic stroke as a presenting complication.
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Primary systemic amyloidosis with ischemic stroke as a presenting complication.

机译:原发性系统性淀粉样变与缺血性中风作为一个并发症。

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摘要

BACKGROUND: Amyloidosis is an uncommon disorder that ultimately leads to fatal multiorgan failure. Ischemic strokes have been sporadically described but are not well characterized. The purpose of this study was to review the pathophysiologic relationship between primary systemic amyloidosis and ischemic stroke, and to determine how often stroke is the first defining manifestation. METHODS: Retrospective study of 49 patients with confirmed primary amyloidosis and ischemic stroke. All included patients had biopsy proven amyloidosis. RESULTS: Forty patients were included in the study. Ischemic strokes occurred in 13 patients (32.5%) as the initial presentation of amyloidosis. Patients with initial stroke presentation had the worst outcome, with average survival of 6.9 months after established diagnosis with amyloidosis; strokes developed 9.6 months before diagnosis with primary amyloidosis. Thirty-seven percent experienced recurrent ischemic stroke. The majority (70%) of patients had cardioembolic infarctions. CONCLUSIONS: Ischemic stroke is an underappreciated complication of primary amyloidosis. In the absence of obvious clinical and cardiogenic manifestations, primary amyloidosis should be considered when echocardiography demonstrates thickening of the valves, restrictive pattern, and increased echogenicity. Ischemic strokes as an initial presentation of primary amyloidosis carries a worse prognosis.
机译:背景:淀粉样变性是一种罕见的疾病最终导致致命multiorgan失败。但不描述的很透彻了。本研究的目的是审查主要病理生理的关系系统性淀粉样变和缺血性中风确定中风通常是第一个定义表现。患者确诊原发性淀粉样变缺血性中风。淀粉样变。包括在这项研究。在13个病人(32.5%)作为初始淀粉样变。最初的中风表现最差的结果,平均生存6.9个月后建立诊断淀粉样变;中风开发9.6个月前诊断原发性淀粉样变。有经验的复发性缺血性中风。多数(70%)的患者cardioembolic梗死灶。被低估的并发症主要淀粉样变。心原性的表现,主要淀粉样变时应该考虑超声心动图显示增厚阀门、限制模式和增加回声。原发性淀粉样变有糟糕的预后。

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