Interactions of stroke, nonsteroidal anti-inflammatory drugs, and APOE status in dementia risk.

摘要

In this issue of Neurology, two independent reports1-2 once again confirm the saliency of the apolipoprotein epsilon 4 (APOE4) allele as a risk factor for Alzheimer disease (AD) or dementia. However, these studies go on to evaluate how APOE4 may be influenced by two other well-known AD/dementia risk factors, one of which, stroke, has been suggested to increase dementia risk,3 and one of which, nonsteroidal anti-inflammatory drug (NSAID) use, has been suggested to decrease AD risk.