CHROMOSOME EVOLUTION IN MALARIA MOSQUITOES

摘要

The genomic era offers excellent opportunities to improve our understanding of the genetic basis of mosquito adaptation, evolution, and competence to a pathogen. The availabihty of polytene chromosomes in anopnelnie mosquitoes makes them an excellentmodel system for studying genome organization, evolution, ana tunction. Physical mapping facilitated the whole genome sequence assembly for the major malaria vector Anopheles gambiae and comparative genome mapping has determined types, patterns, and rates of chromosomal rearrangements m mosquito evolution. Together with sequencing projects, high-resolution physical mapping can shed light on mechanisms of chromosomal rearrangements and phylogenetic relationships among species.