Hyaluronidase and Restylane

摘要

We congratulate Vartanian et al on their investigation of the effects of hyaluronidase on Restylane (Q-Med AB, Uppsala, Sweden), a nonanimal, stabilized hyaluronic acid in test subjects' arms. This excellent work has received the wide attention it deserves, a tribute to Archives' broad readership. A number of misconceptions arising from this study, however, have made their way into common clinical practice and are now even secondarily cited. To support the following comments, we direct readers to 2 articles predating the work of Vartanian et al in which nonpreserved hyaluronidase was documented to effectively diminish Restylane in the face.