Eligibility of patients for CAR T-cell: Expert opinion-based collaborative work by the SFGM-TC

摘要

The chimeric antigen receptor T-cells are a new class of anticancer treatment consisting in genetically modifying autologous or ollogenic T-cells to make express a CAR directed against o membrane tumor antigen. In Europe, tisagenlecleucel (Kymriah (TM)) has a marketing authorization for the treatment of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia in children and young adults and of R/R diffuse large B-cell lymphoma (DLBCL). The marketing authorization for axicobtagene ciloleucel (Yescarta (TM)) is the treatment of DLBCL and primary R/R mediastinol B-cell lymphoma. The two products ore autologous T-cells directed against CD19. This collaborative work, part of a series of expert opinion-based work, aims to give practical advice to help centers in selection of patients for commercially available CAR T-cell treatment.